Monopegylated growth hormone proteins

Details Monopegylated growth hormone proteins Monopegylated growth hormone proteins

2008-07-15

2008-07-15

Rao, Manjunath (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

C514S012200, C530S350000, C530S351000, C530S402000

Reexamination Certificate

active

07399839

ABSTRACT:
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.

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