Monomethylvaline compounds capable of conjugation to ligands

Details Monomethylvaline compounds capable of conjugation to ligands Monomethylvaline compounds capable of conjugation to ligands

2011-06-21

2011-06-21

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019400, C514S019500, C514S019600, C424S178100, C424S179100, C424S181100, C530S391100

Reexamination Certificate

active

07964567

ABSTRACT:
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

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