Monomeric self-associating fusion polypeptides and...

Details Monomeric self-associating fusion polypeptides and... Monomeric self-associating fusion polypeptides and...

2006-10-18

2010-02-23

Woodward, Cherie M (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C530S350000, C536S023500

Reexamination Certificate

active

07666622

ABSTRACT:
Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target ligands include interleukin (IL)-13, IL-1, insulin-like growth factor (IGF)-1 and IGF-2.

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