Monomeric protein of the TGF-β family

Details Monomeric protein of the TGF-β family Monomeric protein of the TGF-β family

2005-12-06

2005-12-06

Andres, Janet (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C514S002600

Reexamination Certificate

active

06972321

ABSTRACT:
The present invention is concerned with proteins selected from the members of the TGF-β superfamily, which are monomeric due to substitution or deletion of a cystein which is responsible for dimer formation. The invention is also concerned with nucleic acids, encoding such monomeric proteins, vectors or host cells containing the nucleic acids as well as with pharmaceutical compositions comprising the proteins or nucleic acids encoding the proteins. The pharmaceutical compositions can be applied advantageously for all indications for which the respective dimeric proteins are useful.

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