Monomeric insulin analog formulations

Details Monomeric insulin analog formulations Monomeric insulin analog formulations

1995-06-01

1998-05-05

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

514 3, 514 4, C07K 1462

Patent

active

057476420

ABSTRACT:
The present invention discloses various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analog, zinc, protamine, and phenolic derivative. The analog formulations provide a prolonged duration of action. A process for preparing insulin analog-protamine formulations is also described.

REFERENCES:
patent: 2538018 (1951-01-01), Krayenbuhl et al.
patent: 2801953 (1957-08-01), Dorzbach et al.
patent: 2849370 (1958-08-01), Petersen et al.
patent: 3060093 (1962-10-01), Poulsen et al.
patent: 3868358 (1975-02-01), Jackson
patent: 5028587 (1991-07-01), Dorschug et al.
patent: 5149777 (1992-09-01), Hansen et al.
patent: 5164366 (1992-11-01), Balschmidt et al.
patent: 5461031 (1995-10-01), De Felippis
patent: 5514646 (1996-05-01), Chance et al.
patent: 5547930 (1996-08-01), Balschmidt
Howey, et al., Diabetes, 43, 396-402 (Mar. 1994).
Diabetes, 41, Suppl. 1, 192A (1992).
Brems, et al., Protein Engineering, 5:6, 519-525 (1992).
Heinemann, et al., Diabetologia, 33, 384-386 (1990).
Kirk-Othmer, Encyclopedia of Chemical Technology, 13, 607-614 (1981).
Bruce H. Frank, Text and Slide copies of lecture given at the Conference on Insulin, Self Association and Conformational Studies on Human Proinsulin and Insulin Analogs, University of York, Aug. 29-Sep. 1, 1989.
Fullerton, et al., Biochim. Biophys. Acta, 214, 141-147 (1970).
Diabetologia, 30, 503A (1987).
Brange, et al., Nature, 333:16, 679-682 (Jun. 1988).
Brange, et al., Diabetes Care, 13:9, 923-954 (Sep. 1990).
Wollmer, et al., Phenol-Promoted Structural Transformation of Insulin in Solution, from the 2nd Assisi International Symposium on Advanced Models for the Therapy of Insulin-Dependent Diabetes, 903-911 (Apr. 1986).
Brange, Galenics of Insulin: The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations, Springer-Verlag Berlin Heidelberg, Germany (1987).
Simkin, et al., Biochimica Et Biophysica Acta, 200, 385-394 (1970).
Brems, et al., Protein Engineering, 5:6, 527-533 (1992).
Chen, et al., Proc. Natl. Sci. Counc, ROC(A), 6:3, 185-189 (1982).
Galloway, et al., Insulin Update, 111-119 (1982).
Balschmidt, et al., Acta Cryst, 975-986 (1991).
Krayenbul, et al., Crystalline Protamine Insulin, (60-73).
Brange, et al., Structural Biology, 1, 934-940 (1991).

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