Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-05-05
1997-03-11
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514177, 514182, 514255, 514299, 536 5, 536 6, 536 62, 546112, 549223, 552506, 552549, 552550, 552551, A61K 31585, C07J 1700
Patent
active
056101511
ABSTRACT:
Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
Monomeric bile acid derivatives of the formula I
REFERENCES:
patent: 4217279 (1980-08-01), Kaiser
patent: 5250524 (1993-10-01), Kramer et al.
Murata et al., "Determination of Sulfated and Nonsulfated Bile Acids in Serum by Mass Fragmentography," Steroids, vol. 42, No. 5, Nov. 1983, pp. 575-592.
De Witt et al., "Effects of sulfation patterns on intestinal transport of bile salt sulfate esters," Chemical Abstracts, vol. 92, No. 8, Abstract No. 073345, 1980, p. 404.
Wess, et al., "Specific Inhibitors of Ileal Bile Acid Transport," Journal of Medicinal Chemistry, vol. 27, No. 7, Apr. 1, 1994, pp. 873-875.
Bartholomew, et al., "The effect of 3-sulfation and taurine conjugation on the uptake of chendeoxycholic acid by rat hepatocytes," Chemical Abstracts, vol. 100, No. 1, Jan. 2, 1984, p. 344.
Ammon et al., "Effects of Sulfodeoxychloate on rat and rabbit small intestine," Chemical Abstracts, vol. 103, No. 1, Jul. 8, 1985, p. 404.
Mazumder et al., "Bile acid transformations by Alcaligenes recti," Steroids, vol. 58, No. 2, Feb. 1993, pp. 79-86.
Babcoc, et al., "Reductive Methylation of Steroid Ketones," Journal of the American Chemical Society, vol. 74, No. 21, Nov. 5, 1952, pp. 5472-5474.
De Weert et al., "Quantitative determination of fecal bile acids as their methyl ether methyl esters by the repetitive scan technique," Chemical Abstracts, vol. 95, No. 3, Jul. 20, 1981.
Pellicciari et al., "Bile Acids with a Cyclopropyl-Containing Side Chain. 1. Preparation and Properties of 3.alpha., 7.beta.-Dihydroxy-22,23-methylene-5.beta.-cholan-24-oic Acid," Journal of Medicinal Chemistry, vol. 27, No. 6, Jun. 6, 1984, pp. 746-749.
Hill et al., Dictionary of Steroids, Indexes, 1991, pp. 386-387.
Redel et al., "Amines cycliques des acides biliares. Premi ere partie:Monoamines,"Bulletin de la Societe Chimique de France (Memoires), 1949, pp. 877-883.
M ullner, et al., "Synthesis of Affinity Chromatography and Electrophoresis Matrices for the Purification of Bile Acid Transport Proteins," Chromatographia, vol. 34, No. 5, Jan. 1993, pp. 819-822.
Crawford et al., "Physical and biological properties of fluorescent dansylated bile salt derivatives: the role of steroid ring hydroxylation," Biochimica et biophysica Acta, vol. 1085, No. 2, Apr. 26, 1991, pp. 223-234.
Ho et al., "Utilising bile acid carrier mechanisms to enhance liver and small intestine absorption," Chemical Abstracts, vol. 110, No. 4, Jan. 23, 1989, p. 330.
Sherman et al., "Hepatic transport of fluorescent molecules: in vivo studies using intravital TV microscopy," Hepatology, vol. 6, No. 3, May-Jun. 1986, pp. 444-449.
Yasuo et al., "Basic bile acids. I. Synthesis and configuration of 3. alpha-aminocholanic acid," Chemical Abstract, vol. 55, No. 4, Feb. 20, 1961, pp. 3648.
Kramer, et al., "Liver-specific Drug Targeting by Coupling to Bile Acids," The Journal of Biological Chemistry, vol. 267, No. 26, Sep. 15, 1992, pp. 18598-18604.
Wess et al., "Synthesis of Bile Acid--Drug Conjugates: Potential Drug--Shuttles for Liver Specific Targeting," Tetrahedron Letters, vol. 34, No. 5, Jan. 1993, pp. 819-822.
Bandiera et al., "A Convenient Procedure for the Synthesis of Ursodeoxycholic Acid Sulfated Derivates," Synthetic Communications, vol. 17, No. 9, 1987, pp. 1111-1117.
Wess et al., "Evaluation of the Bile Acid Transporter in Enhancing Intestinal Permeability to Renin-Inhibitory Peptides," Journal of Drug Targeting, vol. 1, No. 4, Dec. 1993, pp. 347-359.
Kocian et al., "Effect of oral calcium administration on the cholesterol and phospholipid serum levels," Chemical Abstracts, vol. 73, No. 3, 1970, p. 220.
Morishita et al., "Synthesis and Hypolipidemic Activity of 2-Substituted Isobutyric Acid Derivatives," Journal of Medicinal Chemistry, vol. 31, No. 6, 1988, pp. 1205-1209.
Chapman, Jr., et al., "Hypolipidemic Activity of Phthalimide Derivatives V: Reduced and Hydrolytic Products of Simple Cyclic Imides," Journal of Pharmaceutical Sciences, vol. 73, No. 10, Oct. 1984, pp. 1482-1484.
Villegas-Navarro, "9-Anthracenecarboxylic acid and hematological and biochemical variables in the rat," Chemical Abstracts, vol. 112, No. 21, May, 1990, p. 230.
Greisen et al., "Inhibition of .sup.3 H-Glibenclamide Binding to Sulfonylurea Receptors by Oral Antidiabetics," Arzneimittel Forschung Drug Research, vol. 35, No. 4, 1985, pp. 707-712.
Hardison et al., "Specificity of an Na.sup.+ -dependent taurocholate transport site in isolated rat hepatocytes," American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 9, No. 5, May 1984, pp. G477-G483.
Palmieri et al., "Clinical Research into the Hypolipemic and Platelet Antiaggregant Activity of Plafibride, Carried out in Double-blind Conditions and in Comparison with Clofibrate," Arzneimittel Forschung Drug Research, vol. 31, No. 10a, 1981, pp. 1863-1866.
Quackenbush et al., "Arylsulfonate Esters of Fatty Alcohols. II. Structural Relation to Hypocholesterolemic Acitivity," Artery, vol. 3, No. 6, 1977, pp. 553-575.
S. Yamada e tal., "Mild Oxidation of Aldehydes to the Corresponding Carboxylic Acids and Esters: Alkaline Iodine Oxidation Revisited," Tetrahedron Letters, Bd. 33, Nr. 30, Oxford, G. B., pp. 4329-4332 (1992).
G. Wess et al., "Preparation of 3.alpha.-- and 3.beta.-(.omega.-aminoalkoxy)-7.alpha.,12.alpha.-dihydroxy-5.beta.-cholano ic acid esters: Versatile Shuttles for Drug Targeting," Tetrahedron Letters, Bd. 34, Nr. 5, Oxford, G. B., pp. 817-818 (Jan. 1993).
G. Wess et al., "Modified Bile Acids: Preparation of 7.alpha.,12.alpha.-dihydroxy-3.beta.- and 7.alpha.,12.alpha.-dihydroxy-3.alpha. -(2-hydroxyethoxy)-5.beta.-cholanic Acid and Their Biological Activity," Tetrahedron Letters, Bd. 33, Nr. 2, Oxford, G. B., pp. 195-198 (1992).
W. Zhou et al., "Studies on Steroidal Plant-Growth Regulator 25. Concise Stereoselective Construction of Sidechain of Brassinosteroid from the Intact Sidechain of Hyodeoxycholic Acid: Formal Synthesis of Brassinolide, 25-methylbrassinolide, 26,27-bisnorbrassinolide and Their Related Compounds," Tetrahedron Letters, Bd. 48, Nr. 10, Oxford, G. B., pp. 1837-1852 (1992).
W. Kramer et al., "Liver-specific Drug Targeting by Coupling to Bile Acids," Chemical Abstracts, vol. 117, No. 12, abstract no. 118326, (Sep. 21, 1992).
Enhsen Alfons
Glombik Heiner
Kramer Werner
Wess G unther
Covington Raymond
Hoechst Aktiengesellschaft
Ivy C. Warren
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