Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-06-26
2007-06-26
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C435S069100, C435S252300, C435S252330, C435S254800, C435S320100, C530S350000, C536S023500
Reexamination Certificate
active
10751451
ABSTRACT:
This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems includingE. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
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Katsuura Mieko
Kawai Shinji
Kimura Michio
Muraki Yoshifumi
Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pha
Chan Christina
Huynh Phuong
Rothwell Figg Ernst & Manbeck
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