Monolithic capillary electrophoretic device

Details Monolithic capillary electrophoretic device Monolithic capillary electrophoretic device

1993-10-12

1995-07-04

Niebling, John

Chemistry: electrical and wave energy

Apparatus

Coating, forming or etching by sputtering

427 58, 427125, 427255, 4272554, 4272557, 1566571, G25B 900

Patent

active

054297346

ABSTRACT:
A method and apparatus for separating ions in a liquid sample based on electrophoretic mobility. The device includes a buried channel formed upon a semiconductor wafer and surrounded by an insulating material. A matrix liquid is disposed in the channel and facilitates movement of ions through the channel. A voltage source applies a voltage between first and second electrodes mounted in first and second reservoirs, respectively. The first and second reservoirs are located at opposite ends of the channel, and hold the matrix liquid. The applied voltage generates an electric field along the length of the channel that pulls molecules that are introduced into the channel along the channel, such that molecules having one polarity are attracted to the first electrode, and molecules having a second polarity are attracted to the second electrode.

REFERENCES:
patent: 4893509 (1990-01-01), MacIver et al.
patent: 4908112 (1990-03-01), Pace
patent: 5092972 (1992-03-01), Ghowsi
Lee et al. (1990) "Direct Control of the Electroosmosis in Capillary Zone Electrophoresis by Using an External Electric Field", Anal. Chem., 62:1550-1552 (no month).
Manz et al. (1992) "Planar Chips Technology for Miniaturization and Integration of Separation Techniques into Monitoring Systems" (Capillary Electrophoresis on a Chip), J. Chromatog., 593:253-258 (no month).
Li (1992) "Capillary Electrophoresis-principles, practice and applications", J. Chromatog., 52:1-30, 55-139, 145-154, 398-540, 541-553 (no month).

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