Monolactate salts of 4'-(9-acridinylamino)methanesulfon-m-anisid

Details Monolactate salts of 4'-(9-acridinylamino)methanesulfon-m-anisid Monolactate salts of 4'-(9-acridinylamino)methanesulfon-m-anisid

1980-05-23

1982-06-15

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424257, C07D21910, A61K 3147

Patent

active

043352448

ABSTRACT:
This invention concerns three particular crystalline monolactate salts of the antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide. The salts are characterized in having unexpectedly high water-solubility.

REFERENCES:
patent: 3332991 (1967-07-01), Cannon
patent: 4139531 (1979-02-01), Ledochowski et al.
patent: 4150231 (1979-04-01), Ledochowski et al.
Legha et al., Cancer Research, 38, 3712-3716, (11/78).
Von Hoff et al., Cancer Treatment Reports, 62,(10), 1421-1426, (1978).
Issell, Cancer Treatment Reviews, 7, 73-83 (1980).
Lachman et al., The Theory and Practice of Industrial Pharmacy, 2nd ed., Lea & Febiger, Philadelphia, (1976), pp. 521-524.
Cain et al., Europ. J. Cancer, 10, pp. 539-549 (1974).
Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd ed., vol. 12, (1967), p. 174.

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