Monohydrates of aminobenzenesulfonic acid derivatives and method

Details Monohydrates of aminobenzenesulfonic acid derivatives and method Monohydrates of aminobenzenesulfonic acid derivatives and method

1996-12-16

1999-11-23

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514218, 540575, 544392, 544394, 544395, A61K 31495, A61K 3155, C07D295096, C07D24308

Patent

active

059901136

ABSTRACT:
A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurately in manufacturing a pharmaceutical composition for the treatment of heart diseases comprising said monohydrate. ##STR1##

REFERENCES:
patent: 4411904 (1983-10-01), Pattison
patent: 5053409 (1991-10-01), Okushima et al.
patent: 5457107 (1995-10-01), Kaufman
patent: 5486517 (1996-01-01), Downing et al.
Kitamura et al, Chemical Abstracts, vol. 111, No. 23519, 1989.
Okujima et al., Chemical Abstracts, vol. 117, No. 21, Nov. 23, 1992, Abstract No. 212524h, p. 850 JP 04 139 127.

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