Monofunctional polyethylene glycol aldehydes

Details Monofunctional polyethylene glycol aldehydes Monofunctional polyethylene glycol aldehydes

2006-05-09

2006-05-09

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C564S192000, C564S193000, C564S197000, C525S054100, C525S054200, C525S398000, C525S403000, C530S391900

Reexamination Certificate

active

07041855

ABSTRACT:
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.

REFERENCES:
patent: 4528334 (1985-07-01), Knopf et al.
patent: 5135683 (1992-08-01), Cooper
patent: 5252714 (1993-10-01), Harris et al.
patent: 5539063 (1996-07-01), Hakimi et al.
patent: 5990237 (1999-11-01), Bentley et al.
patent: 6437025 (2002-08-01), Harris et al.
patent: 6465694 (2002-10-01), Baudys et al.
patent: 6541543 (2003-04-01), Harris et al.
patent: WO 02/059179 (2002-08-01), None
patent: WO 03/044056 (2003-05-01), None
Vandoorne et al., “Functionalization of α-hydrogen-ω-methoxypoly(oxyethylene),1 A new method for the conversion of hydroxyl end groups into aldehyde groups,”Makromol. Chem., Rapid Commun., 10:271-275 (1989).
Nathan et al., “Copolymers of Lysine and Polyethylene Glycol: A New Family of Functionalized Drug Carriers,”Biconjugate Chem., 4:54-62 (1993).

Affiliated with

Also associated with

Rating

Monofunctional polyethylene glycol aldehydes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monofunctional polyethylene glycol aldehydes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monofunctional polyethylene glycol aldehydes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3532773