Monofunctional polyethylene glycol aldehydes

Details Monofunctional polyethylene glycol aldehydes Monofunctional polyethylene glycol aldehydes

2005-07-12

2005-07-12

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C525S054100, C525S054200, C525S398000, C525S403000, C530S391900

Reexamination Certificate

active

06916962

ABSTRACT:
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.

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