Monofunctional glycosyltransferase of Staphylococcus aureus

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530820, 530825, 4351831, 435 71, 435188, 435 733, 435 30, 435 36, C07K 100, C07K 1400, C07K 1700, G01N 3353, G01N 33569

Patent

active

061438685

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding a novel MTG of Staphylococcus aureus. Also provided are vectors and transformed heterologous host cells for expressing the MTG and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the MTG.

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M. Di Berardino, et al., "The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycansynthesising enzymes" FEBS Letters 392:184-188, (1996).
Paik, et al., "A Putative Monofunctional Glycosyltransferase Is Expressed in Ralstonia eutropha", Journal of Bacteriology 179(12):4061-4065, (1997).
Borchardt, et al., "Sequence analysis of the region downstream from a peptidoglycan hydrolase-encoding gene from Staphylococcus aureus NCTC8325", Gene 137:253-258, (1993).
Goffin et al Microbiology & Molecular Biology Reviews 62/4:1079-1093, 1998.
Van Wageningen et al, Chemistry & Biology 5:155-162, 1998.
Di Guilmi et al, J. Bacteriology, 181/9:2773-2781, 1999.

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