Monofluorinated derivatives of N-propargyl-1-aminoindan and thei

Details Monofluorinated derivatives of N-propargyl-1-aminoindan and thei Monofluorinated derivatives of N-propargyl-1-aminoindan and thei

1994-09-22

1996-01-23

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564428, A61K 31135, C07C21142

Patent

active

054865417

ABSTRACT:
N-propargyl-1-amonoindan monofluorinated in the phenyl ring and their use as selective inhibitors of monoamine oxidase (MAO).
There are provided several processes for the preparation of these novel compounds. There are also provided as novel compounds 1-aminoindans monofluorinated in the phenyl ring, which serve as intermediates in the preparation of the corresponding novel N-propargyl derivatives.

REFERENCES:
patent: 3201470 (1965-08-01), Huebner
patent: 3253037 (1966-05-01), Huebner
patent: 3513244 (1970-05-01), Gittos et al.
Youdim et al., Progress in Medicinal Chemistry, vol. 21, pp. 138-167 (1984).
Youdim et al., Handbook of Experimental Pharmacology, vol. 90, Chapter 3 (1988).
Elsworth et al., Psychopharmacology, vol. 57, pp. 33-38 (1978).
Birkmayer & Riederer, Parkinson's Disease, pp. 138-149 (1983).
Tariot et al., Psychopharmacology, vol. 91, pp. 489-495 (1987).
J. Mendlewicz and M. B. H. Youdim, Brit. J. Psychiat., vol. 142, pp. 508-511 (1983).

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