Monoesters of probucol for the treatment of cardiovascular and i

Details Monoesters of probucol for the treatment of cardiovascular and i Monoesters of probucol for the treatment of cardiovascular and i

1998-05-14

2000-09-19

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514712, 514824, 514825, 514826, 514855, A01N 3702, A61K 3110, A61K 31225

Patent

active

061213195

ABSTRACT:
This invention is a method and composition for the inhibition of VCAM-1, and in particular for the treatment of cardiovascular or inflammatory disease, including atherosclerosis, that includes the administration of an effective amount of an ester of probucol.

REFERENCES:
patent: 3179701 (1965-04-01), Rocklin
patent: 3479407 (1969-11-01), Laufer
patent: 3576883 (1971-04-01), Neuworth
patent: 3952064 (1976-04-01), Whalley
patent: 4029812 (1977-06-01), Wagner
patent: 4076841 (1978-02-01), Wagner
patent: 4078084 (1978-03-01), Wagner
patent: 4115590 (1978-09-01), Lerner
patent: 4752616 (1988-06-01), Hall
patent: 4755524 (1988-07-01), Mueller
patent: 4954514 (1990-09-01), Kita
patent: 5155250 (1992-10-01), Parker
patent: 5206247 (1993-04-01), Regnier
patent: 5262439 (1993-11-01), Parthasarathy
patent: 5380747 (1995-01-01), Medford
patent: 5608095 (1997-03-01), Parker
patent: 5627205 (1997-05-01), Regnier
patent: 5750351 (1998-05-01), Medford
patent: 5773209 (1998-06-01), Medford et al.
patent: 5773231 (1998-06-01), Medford et al.
patent: 5783596 (1998-07-01), Medford et al.
patent: 5792787 (1998-08-01), Medford et al.
patent: 5807884 (1998-09-01), Medford et al.
patent: 5811449 (1998-09-01), Medford et al.
patent: 5821260 (1998-10-01), Medford et al.
patent: 5846959 (1998-12-01), Medford et al.
Baron, J.L. et al., J. Clin. Invest. 93, 1700-1708 (1994).
Brown and Goldstein, Ann. Rev. Biochem. 52, 223 (1983).
Burkly, L.C. et al., Diabetes 43, 523-534 (1994).
Carew et al. Proc. Natl. Acad. Sci. U.S.A. 84:7725-7729 (1987).
Folkman, J. and Shing, Y., Biol. Chem. 10931-10934 (1992).
Heeg et al., Plasma Levels of Probucol in Man After Single and Repeated Oral Doses, La Nouvelle Presse Medicale, 9(40) (1980).
Kazuya et al. J. Lipid Res. 32; 197-204 (1991).
Koch, A.E. et al. Lab. Invest. 64, 313-322 (1991).
Miller, Ann. Rev. Med. 31,97 (1980).
Morales-Ducret, J. et al., Immunol. 149, 1421-1431 (1992).
Ohkawara, Y., et al., Am. j. Respir. Cell Mol. Biol. 12,4-12 (1995).
Oroez, C.G. et al., Immunol. Lett. 32, 7-12 (1992).
Parthasarathy, S. et al., Probucol Inhibits Oxifative Modification of Low Density Lipoprotein, J. Clin. Invest., 77 641-644 (1986).
Patton et al., Clin. Chem. 29, 1980 (1983).
Chemical Abstracts 127:75973, 1996.
Chemical Abstracts 82:86190, 1975.
Chemical Abstracts 126:277465, 1997.
Chemical Abstracts 94:30290, 1980.
Chemical Abstracts 86:5066, 1977.
Chemical Abstracts 122:187387, 1995.
Chemical Abstracts 124:8690, 1996.
Chemical Abstracts 124:146082, 1995.
Chemical Abstracts 110:212254, 1989.

Affiliated with

Also associated with

Rating

Monoesters of probucol for the treatment of cardiovascular and i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoesters of probucol for the treatment of cardiovascular and i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoesters of probucol for the treatment of cardiovascular and i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1073749