Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-04-05
2005-04-05
Leffers, Gerry (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S069100, C435S069300, C435S320100, C435S455000, C435S456000, C435S325000, C424S204100, C424S233100
Reexamination Certificate
active
06875612
ABSTRACT:
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be phagocytized. The vector itself, or cells pretreated with the vector, are useful in all gene medicine applications. Because it is specific for monocytic cells, the inventive vector is particularly suited to vaccine applications. Due to the ability of monocytic cells to target tumors, the inventive vector also is suitable for use in anti-tumor applications, including conventional gene therapy.
REFERENCES:
patent: 6630169 (2003-10-01), Bot et al.
patent: 20020006412 (2002-01-01), Roberts et al.
patent: 0 535 576 (1993-04-01), None
patent: WO 97 11605 (1997-04-01), None
patent: WO 00 60054 (2000-10-01), None
patent: WO 0060054 (2000-10-01), None
Hammond et al. A Particulate Viral Protein Vaccine Reduces Viral Load and Delays Progression to Disease in Immunized Ponies Challenged with Equine Infectious Anemia Virus. Virology 254, 37-49 (1999).*
Furth. Gene Transfer by Biolistic Process. Molecular Biotechnology. 7, 139-143 (1997).*
Jacqueline Guy et al., “Delivery of DNA into mammalian cells by receptor-mediated endocyutosis and gene therapy.”Molecular Biotechnology, 1995. 3(3):236-248. Biosciences Information Service, Philadelphia, PA. DATABASE Biosis Online! (XP002206227).
T. Ragot et al., “Replication-defective recombinant adenovirus expressing the Epstein-Barr virus (EBV) envelope glycoprotein gp340/220 induces protective immunity against EBV-induced Lymphomas in the cottontop tamarin.”J. of General Virology, 1993, 74(3):501-507. Biosciences Information Service, Philadelphia, PA. DATABASE Biosis Online! (XP002206228).
Martine Monteil et al., “Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies.”Vaccine, 2000, 18(17):1738-1742. Biosciences Information Service, Philadelphia, PA. DATABASE Biosis Online! (XP002206229).
Torao Tanaka et al., “Andenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.”Cancer Research, 1996, 56(6):1341-1345. Biosciences Information Service, Philadelphia, PA. DATABASE Biosis Online! (XP002206230).
Kenneth Drazan et al., “Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro.”J. of Surgical Research, 1995, 59(1):219-223. Biosciences Information Service, Philadelphia, PA. DATABASE Biosis Online! (XP002206231).
Lamers et al., Phagocytosis and degradation of DNA-anti-DNA complexes by human phagocytes. I. Assay conditions, quantitative aspects and differences between human blood monocytes and neutrophils.European J. of Immunology, 1981, 11(10):757-764. Database Medline (XP002206232).
Benoit et al., “Studies on the potential of microparticles entrapping pDNA-poly(aminoacids) complexes as vaccine delivery systems.”J. of Drug Targeting, 2001, 9(4):253-266. Database Medline (XP002206233).
E. Scheicher et al., “Uptake of Microparticle-Adsorbed Protein Antigen by Bone Marrow-Derives Dendritic Cells Results in Up-Regulation of Interleukin-1Alpha and Interleukin-12 P40/P35 and Triggers Prolonged, Efficient Antigen Presentation.”European J. of Immunology, Weinheim, DE.
Wagner Thomas E.
Yu Xianzhang
Greenville Hospital System
Leffers Gerry
Marvich Maria
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