Monocyte cell

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

07833789

ABSTRACT:
The present invention relates to human and mouse monocyte cells expressing Tie2 and CD14 or CD16 and their use in methods for regulating angiogenesis and vascular integrity, such as methods of inducing angiogenesis, promoting vessel growth or stabilization, treating pathological disorders, inhibiting angiogenesis, and diagnosing or monitoring a pathological disorder.

REFERENCES:
patent: 2003/0077249 (2003-04-01), Bebbington et al.
Fujiyama et al., 2003, Circulation Research, vol. 93, p. 980-989.
Weber et al., 2000, Journal of Leukocyte Biology, vol. 67, p. 699-704.
Taussig et al., “Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia,”Blood, vol. 106, p. 4086-4092 (2005).
Wild et al., “Quantitative Assessment of Angiogenesis and Tumor Vessel Architecture by Computer-Assisted Digital Image Analysis: Effects of VEGF-Toxin Conjugate on Tumor Microvessel Density,”Microvascular Research, vol. 59, p. 368-376 (2000).
Arai et al., “Tie2/Angiopoetin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche,”Cell, vol. 118, p. 149-161 (2004).
Elsheikh et al., “Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity,”Blood, vol. 106, p. 2347-2355 (2005).
Gordon et al., “Monocyte and Macrophage Heterogeneity,”Nature Reviews Immunology, vol. 5, p. 953-964 (2005).
Jones et al., “The Receptors: New Modulators of Angiogenic and Lymphangiogenic Responses,”Nature Reviews Molecular Cell Biology, vol. 2, p. 257-267 (2001).
Lemieux et al., “Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses,”Blood, vol. 105, p. 1523-1530 (2005).
Rafii et al., “Vascular and Haematopoietic Stem Cells: Novel Targets for Anti-Angiogenesis Therapy?”Nature Reviews Cancer, vol. 2, p. 826-835 (2002).
De Palma et al., “Tie 2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors,”Cancer Cell, vol. 8, p. 211-226 (2005).

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