Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-12-16
1996-07-30
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303891, A61K 3516
Patent
active
055412963
ABSTRACT:
This invention relates to a method for the prevention of monocyte adherence to the endothelial cells lining blood vessels, their subsequent invasion of surrounding tissues and diseases related thereto. It comprises inducing a monocyte adhesion protein to the surface of endothelial cells by treatment with specific cytokines, preparing a monoclonal antibody to the monocyte adhesion protein and contacting the antibody to the protein to form a complex. The monoclonal antibody does not bind to the cell surface proteins VCAM or ELAM. The complex results in a decrease in the adherence of monocytes to endothelial cells and thereby attenuates or prevents the harmful effects of monocyte invasion of endothelial cells and surrounding tissues.
REFERENCES:
Martiney Faseb J 5(4) A624 Abst 1469 1991.
Calderon Circulation 82(4):III-94 Abst 0368 1990.
Dixit et al JBC 265(5) 2973-2978 1990.
Lerner Nature 299:592-596 1982.
Harris et al. TibTech 11:42-44 1993.
Wabmann Science 252:1657-1662 1991.
Dialog Dissertation Abstract James A. Martiney.
Berman Joan W.
Calderon Tina M.
Adams Donald E.
Albert Einstein College of Medicine of Yeshiva University (a Div
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