Monocyclic functional dyes for contrast enhancement in optical i

Details Monocyclic functional dyes for contrast enhancement in optical i Monocyclic functional dyes for contrast enhancement in optical i

1996-05-13

1998-03-03

Kight, John

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

424 91, 424 111, A61K 4900, G01N 3100, G01N 3348

Patent

active

057231044

ABSTRACT:
This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, C.sub.1 -C.sub.10 carboxylalkyl, C.sub.1 -C.sub.10 alkyl sulfonate, mercapto alkyl and --(CH.sub.2).sub.m N(R.sup.6)(R.sup.7); X is --O--, --NR.sup.8, or --S--; W.sup.1 and W.sup.2 may be the same or different and are selected from the group consisting of --S--, --O--, --NR.sup.8 and C(R.sup.9)(R.sup.10); p is about 1-10; and m is about 0-10; R.sup.8 is hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, C.sub.1 -C.sub.10 mercaptoalkyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, C.sub.1 -C.sub.10 carboxylalkyl, C.sub.1 -C.sub.10 alkoxycarbonyl, C.sub.1 -C.sub.10 alkylthio, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7); and R.sup.9 and R.sup.10 are independently hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 carboxyalkyl, C.sub.1 -C.sub.10 alkoxycarbonyl, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7).

REFERENCES:
patent: 4762701 (1988-08-01), Horan et al.
Tikhonov et al(1972), Kvantovaya Elektron (Kiev), No. 6, pp.48-71, "Pulse lasers with solutions of organic dyes in the region 7100-11,000 Ang".
Bereza et al.(1971), Zh. Pr.Kl.Spektvosk, vol. 15, No. 4, pp. 630-635, "Optimium conditions for laser generation in solutions of organic compounds for the 7100-11,000 Ang spectral region".
Dyadyusha et al (1971), Pisma zh. Eksp. Teor. Fiz., vol. 14, No.5, pp. 330-333, "Intensive fluorescence from the second excited state of molecular solutions of organic dyes".
Shuleznko (1968), Zh. Org. Khim.,vol.4, No.12, pp.2207-2212, "Cyanine dyes containing a thiophene ring in the polymethine chain".
T. Khonor et al (1967), Ukr. F,Z.Zh (Ukr. Ed.), vol. 12, No. 12, pp.2077-2079, "Stimulated light emission by dilute solutions of polymethine dyes."

Affiliated with

Also associated with

Rating

Monocyclic functional dyes for contrast enhancement in optical i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monocyclic functional dyes for contrast enhancement in optical i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monocyclic functional dyes for contrast enhancement in optical i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2245436