Monocyclic anilide spirolactam CGRP receptor antagonists

Details Monocyclic anilide spirolactam CGRP receptor antagonists Monocyclic anilide spirolactam CGRP receptor antagonists

2005-09-06

2010-02-09

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S211030, C514S218000, C514S228800, C514S256000, C514S365000, C514S372000, C514S385000, C514S404000, C514S422000, C544S097000, C544S298000, C546S017000, C548S213000, C548S225000, C548S255000, C548S311100, C548S356100, C548S357500, C548S366100, C548S408000, C548S517000, C548S541000, C540S488000, C540S492000

Reexamination Certificate

active

07659300

ABSTRACT:
The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5band R5care as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

REFERENCES:
patent: 5064852 (1991-11-01), Howard et al.
U.S. Appl. No. 11/662,703, commonly assigned to Merck & Co., Inc., filed Mar. 13, 2007.

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