Monocyclic and bicyclic himbacine derivatives useful as...

Details Monocyclic and bicyclic himbacine derivatives useful as... Monocyclic and bicyclic himbacine derivatives useful as...

2011-02-15

2011-02-15

Davis, Zinna N (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S330000, C546S339000

Reexamination Certificate

active

07888377

ABSTRACT:
Monocyclic and bicyclic himbacine derivatives of the formulaor a pharmaceutically acceptable salt or solvate of said compound whereinrepresents an optional double bond and wherein Gn, Jn, R3, R8, R9, R10, R11, R32, R33, B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed.

REFERENCES:
patent: 6063847 (2000-05-01), Chackalamannil
patent: 6326380 (2001-12-01), Chackalamannil
patent: 6645987 (2003-11-01), Chackalamannil et al.
patent: 7037920 (2006-05-01), Chackalamannil
patent: WO 94/03479 (1994-02-01), None
patent: WO 01/96330 (2001-12-01), None
patent: WO 03/033501 (2003-04-01), None
patent: WO 2004092100 (2004-10-01), None
patent: WO 2005/030712 (2005-04-01), None
Clasby et al., “Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core”, Bioorganic & Medicinal Chemistry Letters, 17(13): 3647-3651 (2007).
Xia et al., “Himbacine derived thrombin receptor(PAR-1)antagonists: Structure-activity relationship of the lactone ring”, Bioorganic & Medicinal Chemistry Letters, 16(18): 4969-4972 (2006).
International Search Report dated Oct. 19, 2007 for corresponding PCT Application No. PCT/US2007/007497.
Bensaid et al., “The Cannabinoid CB1Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells”, Molecular Pharmacology, 63(4): 908-914 (2003).
Bernatowicz et al., “Development of Potent Thrombin Receptor Antagonist Peptides”,J. Med. Chem., 39: 4879-4887 (1996).
Chackalamannil, “A Highly Efficient Total Synthesis of (+)-Himbacine”,J. Am. Chem. Soc., 118: 9812-9813 (1996).
Pertwee, “Pharmacology of Cannabinoid Receptor Ligands”,Current Medicinal Chemistry, 6(8): 635-664 (1999).

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