Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-10-18
1990-03-06
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436514, 436536, 436537, 436547, 436548, 43524027, 530387, 530828, 530806, G01N 3353, G01N 33542, G01N 33546, G01N 33574
Patent
active
049065629
ABSTRACT:
The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. Also disclosed in a novel glycolipid antigen. The invention also comprises a method for determining the presence of a malignant condition in lung tissue and other human tissue. The method involves examining the human tissue for the presence of a glycolipid antigen having the terminal carbohydrate sequence: GalNAc.beta.l.fwdarw.4Gal.beta.l.fwdarw.3GalNAc.beta.l.fwdarw.4Gal.beta.l. fwdarw.R.
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Brown Joseph P.
Hellstrom Ingegerd
Hellstrom Karl E.
Horn Diane
Linsley Peter
Kushan Jeff
Moskowitz Margaret
Oncogen
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