Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-10-17
2006-10-17
Ewoldt, G. R. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388350, C530S809000
Reexamination Certificate
active
07122638
ABSTRACT:
Disclosed herein are hydridoma cell lines producing monoclonal human natural IgM antibodies and methods of use thereof. The antibodies are the monoclonal equivalents of circulating human natural antibodies. Also disclosed herein are pharmaceutical formulations and methods for treating HIV-1 infected individuals using the monoclonal human natural antibodies.
REFERENCES:
patent: 4997764 (1991-03-01), Dalla Favera
patent: 5606026 (1997-02-01), Rodman
patent: 5656272 (1997-08-01), Le et al.
patent: WO-93/22349 (1993-11-01), None
Hua Liu, et al., “Production of anti-tumor human monoclonal antibodies using different approaches”, Human Antibodies and Hybridomas, Jan. 1993, vol. 4, pp. 2-8.
Kari Siemoneit, et al., “Isolation and Epitope Characterization of Human Monoclonal Antibodies to Hepatitis C Virus Core Antigen”, Hybridoma, Feb. 1994, vol. 13, No. 1, pp. 9-13.
Karen Dahl, et al., “Differences among Human Immunodeficiency Virus Strains in Their Capacities to Induce Cytolysis or Persistent Infection of a Lymphoblastoid Cell Line Immortalized by Epstein-Barr Virus,” Journal of Virology, May 1987, vol. 61, No. 5, pp. 1602-1608.
Michelle S. Glasky, et al., “Stability of Specific Immunoglobulin Secretion by EBV-Transformed Lymphoblastoid Cells and Human-Murine Heterohybridomas”, Hybridoma, Aug. 1989, vol., 8, No. 4, pp. 377-389.
Almond, N.M. and J.L. Heeney. 1998. Aids vaccine development in primate models,Aids12: (suppl.A) S133.
Bendelac, A. and D.T. Fearon, 1997. Innate immunity. Innate pathways that control acquired immunity.Curr. Opinion Immunol. 9:1-3.
Cao,Y.et al. 1995. Virologic and immunologic characterization of long-term survivors of humna immunodeficiency virus type 1 infection.New Eng.J.Med. 332:201-208.
Carroll, M.C. et al. 1998. Linkages of innate and adaptive immunity.Curr. Opinion Immunol. 10:36-40.
Chen, P., M.Mayne, C. Power and A.Nath. 1997. The Tat protein of HIV-1 induces tunor necrosis factor alpha production. Implications for HIV-associated neurologic diseases.J. Biol. Chem. 272:22385-22388.
Coutinho, A. et al., 1995. Natural antibodies.Curr. Opinion Immunol. 7:812-818.
Crouau-Roy, B., et al. 1996. A fine-scale comparison of the human and chimpanzee genomes: linkage disequilibrium and sequences analysis.Hum. Mol. Genet. 5:1131-1137.
Cullen, B.R. 1991. Regulation of human immunodeficiency virus replication.Ann.Rev. Microbiol. 45:219-250.
Donahue, R.E., et al. 1998. Reduction in SIV replication in rhesus macaques infused with autologous lymphocytes engineered with antiviral genes.Nat. Med. 4:181-186.
Ehret, A., et al. 1996. Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis.J. Virol. 10:6502-6507.
Frankel, A.D. et al. 1988. Cellular uptake of the tat protein from human immunodeficiency virus.Cell55:1189-1193.
Frankel, A.D., et al. 1989. Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1.Proc.Natl.Acad.Sci. USA. 86:7397-7401.
Ghandi, R.T. et al. 1998. HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism.J.Exp.Med. 187:1113-1122.
Gougeon, M.L., et al. 1996. Comparative analysis of apoptosis in HIV-infected humans and chimpanzees: relation with lymphocyte activation.Immunol. Lett. 51:75-81.
Heilman, C.A. et al. 1998. HIV vaccines—Where are we going?Nat. Med. 4:532-534.
Herbein, G., et al. 1998. Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T Iymphocytes.J. Virol.72:660-670.
Hulskotte, E.G.J, et al. 1998. Towards and HIV vaccine: lessons from studies in macaque models.Vaccine16:904-915.
Iida, T., et al. 1998. Fas antigen expression and apoptosis of lymphocytes in macaques infected with simian immunodeficiency virus strain mac.Arch. Virol. 143:717-729.
Janeway, C.R.Jr. 1998. Presidential address to the American Association of Immunologists. The road less traveled by: the Role of innate immunity in the adaptive immune response.J. Immunol. 161:539-544.
Klein, L., e tal. 1998. CD4T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium.J.Exp.Med. 188:5-16.
Kuppuswamy, M., et al. 1989. Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis.Nucl.Acids Res. 17:3551-3561.
Matzinger, P, 1994. Tolerance, danger and the extended family.Ann Rev. Immunol. 12:991-1045.
McCune, J.M. Animal models of HIV-1 disease. 1997.Science279:2141-2142.
Medzhitov, R. et al. 1997. Innate immunity: impact on the adaptive immune response.Cur. Opinion Immunol. 9:4-9.
Mohri, H., et al. 1998. Rapid turnover of T Iymphocytes in SIV infected rhesus macaques.Science279:1223-1227.
Montefiori, D.C., et al. 1996. Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors.J.Infect.Dis. 173:60-67.
New, D.R., et al. 1997. Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary neuron cultures.J. Neurovirol. 168-173.
Noraz,N., et al. 1997. HIV-induced apoptosis of activated primary CD4+ T lymphocytes is not mediated by Fas-Fas ligand, AIDS 11:1671-1680.
Novembre,F.J., et al. 1997. Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1 infected with human immunodeficiency virus type 1.J. Virol. 71:4086-4091.
Parker, W., et al.1996. Isohemagglutinins and xenoreactive antibodies. Members of a distinct family of natural antibodies.Human.Immunol. 45:94-104.
Rodman, T.C., et al. 1997. innate natural antibodies. Primary roles indicated by specific epitopes.Human Immunol. 55:87-95.
Rosenzweig, M., et al. 1998. Increased rates of CD4+ and CD8+ T Iymphocyte turnover in simian immunodeficiency virus-infected macaques.Proc. Natl. Acad. Sci. USA. 95:6388-6393.
Samuelsson,A., et al. 1997. Apoptosis of CD4 and CD19+ cells during human immunodeficiency virus type-1 infection—correlation with clinical progression, viral loas and loss of humoral immunity.Virology238:180-188.
Steinman, R.M. et al. 1998. Antigen presentation and related immunological aspects of HIV-1 vaccines.AIDS12:(suppl.A) S97-S112.
Taylor, M.D., et al. 1998. Interferon treatment inhibits the replication of simian immunodeficiency virus at an early stage: evidence for a block between attachment and reverse transcription.Virology241:156-162.
Van Parijs, L. et al. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off.Science280:243-248.
Vives, E., et al. 1997. A truncated HIV-1 Tat protein basic domain repidly translocates through the plasma membrane and accumulates in the cell nucleus.J. Biol. Chem. 272:16010-16017.
Wessenlingh, S.L., et al. 1997. Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcription/polymerase chain reaction in situ hybridization and immunohistochemistry.J.Neuroimmunol. 74: 1-8.
Chiorazzi N, et al. Use of Epstein-Barr virus-transformed B-cell lines for the generation of immunoglobulin-producing human B cell hybridomas.J Exp Med156:930-935, 1982.
Aitken R.J., Fertilization and early embryogenesis. In Hillier SG, Kitchener HC, Neilson JP, Eds. Scientific Essentials of Reproductive Medicine. London: W.B.Saunders, p219-229, 1996.
Atherton D., et al. Routine protein sequence analysis below ten picomoles: one sequencing facility's approach. p. 409-418,1993, Techniques in Protein Chem IV.
Baker E.N. et al., Three-dimensional structure of lactoferrin in various functional states.Adv Exp Med Biol 357:1-12, 1994.
Beavis RC, Chait BT. High-accuracy molecular mass determination of proteins using matrix-assisted desorption mass spectrophotometry.Anal Chem 62:1836-1840, 1990.
Bi By, et al., Internalization of human lactoferrin by the Jurkat human lymphoblastic T cell line.Eur J Cell Biol 69:288-296, 1996.
Boyden SV. Natural antibodies and the immune response.Adv Immunol 5:1-28, 1966.
Chiorazzi N, Generation of stable autoantibody-secreting B cell hybridomas.Mol Biol Reports 1
Darby & Darby
Ewoldt G. R.
The Institute for Human Genetics and Biochemistry
LandOfFree
Monoclonal human natural antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal human natural antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal human natural antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3664349