Monoclonal antibody with a high affinity for digoxin

Details Monoclonal antibody with a high affinity for digoxin Monoclonal antibody with a high affinity for digoxin

1984-08-13

1987-10-27

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351722, 435948, 43524027, 530384, 436548, 935104, C12P 2100, C12N 1500, C12N 500, C12R 191

Patent

active

047030038

ABSTRACT:
A hybridoma which produces monoclonal antibodies having a high affinity and selectivity for digoxin is produced by immunizing mice with digoxin, fusing the spleen cells from the treated mice with mice myeloma cells, separating hybrids from non-fused cells, selecting the hybrids which produce monoclonal antibodies directed against digoxin and isolating the hybrids.

REFERENCES:
patent: 4477576 (1984-10-01), Deutsch et al.
Hunter et al. "High-Affinity Monoclonal Antibodies to the Cardiac Glycoside Digoxin" 1982, J. of Immunology, vol. 129, pp. 1165-1172.
Bang et al. "Studies of Monoclonal and Polyclonal Anti-Digoxin Antibodies for Serum Digoxin RIA" 1981, Scand J. Clin. Lab. Invest., vol. 41, pp. 75-78.
Zakberg et al. "Monoclonal Antibodies to Drugs-Digoxin" 1983, Int. J. Immunopharmac., vol. 5, pp. 397-402.
Margolies et al. "Monoclonal Antibodies to the Cardiac Glycoside Digoxin" 1981, Res. Monogr. Immunology (3) pp. 367-374.

Affiliated with

Also associated with

Rating

Monoclonal antibody with a high affinity for digoxin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibody with a high affinity for digoxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody with a high affinity for digoxin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1272081