Monoclonal antibody which inhibits the adhesion functions of the

Details Monoclonal antibody which inhibits the adhesion functions of the Monoclonal antibody which inhibits the adhesion functions of the

1991-05-22

1993-06-15

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

53038873, 53038875, 53038822, C12P 2108, C07K 1528

Patent

active

052199975

ABSTRACT:
A hybrid cell line is developed which produces a monoclonal antibody which binds to a unique antigenic site expressed on the surface of phagocytic cells. The monoclonal antibody binds to and activates a specific domain of the CD11b glycoprotein so as to inhibit adhesion dependent functions of the phagocytic cell, but it does not affect other phagocytic functions. This monoclonal antibody can be used as a reactant in an in vitro diagnostic immunoassay for detecting the unique antigenic site on the surface of normal human neutrophils.

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