Monoclonal antibody which distinguishes helper inducer and suppr

Details Monoclonal antibody which distinguishes helper inducer and suppr Monoclonal antibody which distinguishes helper inducer and suppr

1989-11-28

1992-06-09

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 11, 424 8591, 435 79, 435 34, 4351722, 43524027, 435948, 436548, 530809, 53038875, 53038873, 5303887, 935110, C07K 1528, C12N 520, G01N 33577

Patent

active

051206420

ABSTRACT:
A monoclonal antibody which binds preferentially to a subset of the human CD4+ lymphocyte population whereby to positively and precisely distinguish between helper-inducer and suppressor-inducer cells in the CD4+ cell population. The monoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which express the antigen on the surface of CD4+ cells. The CD4+ subset cell population to which this antibody preferentially binds is the CD4+ helper-inducer population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and possible therapeutic applications thereof to be realized. The monoclonal antibody also reacts with CD8 cells, B cells and macrophages.

REFERENCES:
patent: 4661446 (1987-04-01), Schlossman et al.
patent: 4677056 (1987-06-01), Dupont et al.
D. A. Fox et al, Jour. Immunol., 133, 1250-1256, 1984.
C. Morimoto et al, Jour. Immunol., 134, 7508-1515, 3762-3769, 1985.
S. H. Smith et al, Immunolology, 58, 63-70, 1986.

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