Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
2000-01-10
2000-12-26
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038822, 435334, 435331, 4353432, C12N 512, C07K 1644
Patent
active
061661864
ABSTRACT:
The present specification provides a means for specifying the condition and type of immune-related diseases on the basis of knowledge about the polarization of the distribution of helper T-cell subsets Th1 and Th2. More specifically, the gene (B19), specific only to the human Th2, is prepared by a subtraction method. A human-Th2-specific protein which the gene encodes is produced by recombinant methods, and a monoclonal antibody against the Th2-specific protein and a hybridoma which produces the monoclonal antibody is provided.
REFERENCES:
J. Thomas Ngo, et al. 14 Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, The Protein Folding Problem and Tertiary Structure prediction, Birkhauser Boston 1994, pp. 492-495.
Kazuko Yoshida, et al., Studies on Natural ST2 Gene products in the Human Leukemic Cell Line UT-7 Using Monoclonal Antihuman ST2 Antibodies, Hybridoma, vol. 14, No. 5, 1995, Mary Ann Liebert, Inc. pp. 419-427.
Damo Xu, et al., Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells, The Rockefeller University Press, J. Exp. Med. vol. 187, No. 5, Mar. 2, 1998 pp. 787-794.
Nagata Kinya
Ogawa Kazuyuki
Takano Syoichi
Tanaka Kazuya
BML, Inc.
DeCloux Amy
Saunders David
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