Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-07-26
2005-07-26
Devi, S. (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S388100, C530S388400, C424S139100, C424S150100, C424S130100, C424S141100
Reexamination Certificate
active
06921809
ABSTRACT:
The present invention related to biotechnology and genetic engineering, particularly the expression of proteins of viral origin in microorganisms through their fusion by applying recombinant DNA technology to bacterial peptides. The present invention provides an effcient process for the expression inEscherichia coliof heterlogous proteins as fusion peptides with a view to obtaining them with a high degree of purity, in commercially useful amounts, and in an appropriate form for their inclusion in vaccine preparations. What is essentially used is a stabilizing sequence derived from the first 47 amino acids of the antigen P64k ofNeisseria meningitidesB:4:P1.15. In particular, use is made of a recombinant plasmid containing said sequence, under the control of the tryptophane promoter ofE. coliand of the terminator of the transcription of the phage T4, including restrictions sites which provide for the cloning in phase of DNA fragments coding for polypeptides of interest.
REFERENCES:
patent: 0 474 313 (1992-11-01), None
Niebla et al. In: Neisseria 94. Proceedings of the Ninth International Pathogenic Neisseria Conference. (Ed) Evans et al. Winchester, England, Sep. 26-30, 1994, pp. 85-86.
Nazabal et al. In: Neisseria 94. Proceedings of the Ninth International Pathogenic Neisseria Conference. (Ed) Evans et al. Sep. 26-30, Winchester, England, pp. 98-99, 1994.
Acosta Anabel Alvarez
Angulo Maria De Jesus Leal
Cano Carlos Antonio Durate
Dunn Alejandro Miguel Martin
Galvez Consuelo Nazabal
Centro de Ingenieria Genetica y Biotechnologia
Devi S.
Lackenbach & Siegel LLP
LandOfFree
Monoclonal antibody to the stabilizer peptide of the P64K... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody to the stabilizer peptide of the P64K..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody to the stabilizer peptide of the P64K... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3423664