Monoclonal antibody to the interleukin-2-receptor and its use

Details Monoclonal antibody to the interleukin-2-receptor and its use Monoclonal antibody to the interleukin-2-receptor and its use

1989-04-25

1992-01-28

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 435 792, 530387, 530388, 424 852, 424 858, C12N 520, C07K 1528

Patent

active

050843915

ABSTRACT:
New monoclonal murine-IgG.sub.1 antibody obtainable from a new hybridoma-cell line, binding to an epitope of the human interleukin-2 receptor that differs from Tac, inhibiting the binding of human interleukin-2 to its receptor, and appropriate for the treatment, prophylaxis, and diagnosis of interleukin-2-dependent diseases in humans.

REFERENCES:
patent: 4578335 (1986-03-01), Urdal et al.
Kohler & Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, vol. 256 (1975) 495-497.
Anasetti, Martin et al., "A Phase I-II Study Evaluating the Murine Anti-IL-2 . . . ", Transplantation (1990), pp. 49-54.
Herve, Wijdenes et al., "Treatment of Corticosteroid Resistant Acute Graft-Versus-Host . . . ", Blood, vol. 75 (1990), pp. 1017-1023.
Transplantation Proceedings, vol. 23, No. 1 (Feb.) 1991, pp. 1692-1694.
The Lancet, Nov. 5, 1988, pp. 1072-1073.

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