Monoclonal antibody to oncofetal protein for treating and detect

Details Monoclonal antibody to oncofetal protein for treating and detect Monoclonal antibody to oncofetal protein for treating and detect

1995-05-26

1997-08-12

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 5303877, 53038885, G01N 33574, G01N 3353, C07K 1630, C07K 1618

Patent

active

056564449

ABSTRACT:
The present invention provides a low cost, less toxic, anti-cancer immunotherapy which enhances the host's immune system ability to destroy or contain cancers, and also provides a diagnostic test for cancer. Specifically, the present invention provides monoclonal antibodies specific for, that is, specifically bind, oncofetal protein (OFP), a cancer cell product. Tumors treated with a single dose of the monoclonal antibodies against OFP are markedly reduced in size, and leukemic populations of cells treated with a single does of monoclonal antibodies against OFP are significantly decreased in number. Since the monoclonal antibodies of the present invention do not bind to tumor cells, the monoclonal antibody treatment overcomes the disadvantages associated with tumor cell targeting. Monoclonal antibodies to OFP offer a simple and inexpensive agent for use as a primary or adjuvant therapy against a wide variety of cancers and tumors in humans and other animals. The monoclonal antibodies against OFP are also employed to detect cancer in animal, including human patients.

REFERENCES:
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patent: 5310653 (1994-05-01), Hanausek-Walazek et al.
Steve Runge's thesis "Characterization of an Oncofetal Protein (OFP) and Cloning of its cDNA" pp. 76-113, cataloged at Ohio State University, Jul. 30, 1992.
Oredipe, O.A., et al. Carcinogenesis, 10(12): 2175-2181, Dec., 1989.
Abstract #1311, Schumm, D.E., Proc. Ann. Meet. Am.Assoc. Ca. Res. 33:A1311, Mar. 1992.
Abstract #1515, Schumm, D.E., et al. "Characteristics of an Oncofetal Tumor Marker Protein", Proc. Am. Assoc. Ca. Res. 31: 256, Mar. 1990.
Abstract #1669, Runge, S.W., et al., "Characterization of an Oncofetal Protein (OFP) and Cloning of Its cDNA", Proc. Am. Assoc., Ca. Res. 32: Mar. 1991.
Abstract #7502, Runge, S.W., et al. "Characterization of an Oncofetal Protein (OFP) and Cloning of Its cDNA", 75th Annual Meeting of Assoc. of Biochem. and Mol. Biol. FASEB, Apr. 1991.
Runge, S., et al. "Development and Use of Monoclonal Antibodies Against an Oncofetal Protein Associated with Carcinogenesis and Tumorgenesis" Immunlogical Investigation, 20(3):269-286 (1991).
Stomberg, Paul C., et al. "Expression of an Oncofetal Protein (OFP) in Rat and Human Leukemia Cells", Leukemia Research, vol. 15, pp. 427-433 (1991).

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