Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1994-09-13
1997-07-08
Knode, Marian C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
53038815, 5303883, 4351722, 435 7021, C07K 1600, C12N 500, C12N 1500, C12P 2104
Patent
active
056460414
ABSTRACT:
Human Monoclonal antibodies effective for the diagnosis and treatment of Herpes Simplex Virus 1 and 2 have been prepared from a cell line obtained by fusing a xenogeneic hybridoma designated SPAZ 4 with spleen cells of a patient immune to Herpes Simplex Virus.
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Su et al. "Protective Antibody Therapy is Associated with Reduced Chemokine Transcripts in Herpes Simplex Type 1 Corneal Infection", 1996, Journal of Virology, vol. 70, No. 2, pp. 1277-1281. *Abstract Only.
Co et al., "Humanized Antibodies for Antiviral Therapy", 1991, Proceedings of the National Academy of Sciences of the United States of America, vol. 88, No. 7, pp. 2869-2873. *Abstract Only.
Sanna et al., "Directed Selection of Recombinant Human Monoclonal Antibodies to Herpes Simplex Virus Glycoproteins From Phage Display Libraries", 1995, Proceedings of the National Academy of Sciences of the United States of America, vol. 92, No. 14, pp. 6439-6443.
Staats et al., "Anti-Glycoprotein D Monoclonal Antibody Protects Against Herpes Simplex Virus Type 1-Induced Diseases in Mice Functionally Depleted of Selected T-Cell Subsets or Asialo GM1+ Cells", Journal of Virology, 1991, vol. 65, No. 11, pp. 6008-6014.
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Seigneurin et al. Science 221:173-175, 1983.
Goding, "Monoclonal Antibodies: Principles and Practice", Academic Press, 1983 pp. 118-123.
Harfeldt Elisabeth
Lake Philip
Nottage Barbara
Ostberg Lars G.
Knode Marian C.
Williams Jay
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