Monoclonal antibody to canine placental oncofetal protein for de

Details Monoclonal antibody to canine placental oncofetal protein for de Monoclonal antibody to canine placental oncofetal protein for de

1994-04-01

1996-07-02

Feisee, Lila

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435721, 5303877, 53038885, C12N 512, C12P 2108, C07K 1618, C07K 1630

Patent

active

055321593

ABSTRACT:
The present invention provides a low cost, less toxic, anti-cancer immunotherapy which enhances the host's immune system ability to destroy or contain cancers, and also provides a diagnostic test for cancer. Specifically, the present invention provides monoclonal antibodies specific for, that is, specifically bind, oncofetal protein (OFP), a cancer cell product. Tumors treated with a single dose of the monoclonal antibodies against OFP are markedly reduced in size, and leukemic populations of cells treated with a single does of monoclonal antibodies against OFP are significantly decreased in number. Since the monoclonal antibodies of the present invention do not bind to tumor cells, the monoclonal antibody treatment overcomes the disadvantages associated with tumor cell targeting. Monoclonal antibodies to OFP offer a simple and inexpensive agent for use as a primary or adjuvant therapy against a wide variety of cancers and tumors in humans and other animals. The monoclonal antibodies against OFP are also employed to detect cancer in animal, including human patients.

REFERENCES:
patent: 4746539 (1988-05-01), Webb et al.
patent: 4871661 (1989-10-01), Webb et al.
patent: 5310653 (1994-05-01), Hanausek-Walaszek et al.
Abstract #1515, Schumm D. E., Larroya S. and Webb, T. E., "Characteristics of an Oncofetal Tumor Marker Protein." Proc. Am. Assoc. Ca. Res. 31: 256, Mar. 1990.
Abstract #1669, Runge, S. W., Larroya-Runge, S. N., Webb T. E., and Schumm, D. E., "Characterization of an Oncofetal Protein (OFP) and Cloning of Its cDNA," Proc., Am. Assoc., Ca., Res. 32, Mar., 1991.
Abstract #7502, Runge, S. W., Larraya-Runge S. N., Webb, T. E., and Schumm D. E., "Characterization of Oncofetal Protein (OFP) and Cloning of Its cDNA," 75th Annual Meeting of Assoc. of Biochem. and Mol. Biol., FASEB, Apr., 1991.
Steven Runge's thesis entitled "Characterization of an Oncofetal Protein (OFP) and Cloning of its cDNA," pp. 76-113, cataloged at Ohio State University, Jul. 30, 1992.
Runge, Steven W. et al. "Development And Use Of Monoclonal Antibodies Against An Oncofetal Protein Associated With Carcinogenesis And Tumorigenesis," Immunological Investigations, 20(3):269-286 (1991).
Stomberg, Paul C. et al. "Expression of An Oncofetal Protein (OFP) In Rat And Human Leukemia Cells," Leukemia Research, vol. 15., pp. 427-433 (1991).
Thesis by Steven Runge entitled: "Characterization of an Oncofetal Protein (OFP) and Cloning of its cDNA", pp. 1-210, cataloged at the Ohio State University library on Jul. 20, 1992.
Oredipe, O. A. et al., Carcinogenesis, 10(12):2175-2181, 1989.
Schumm, D. E., Proc. Ann Meet Am Assoc Can Res, 33:A1711, 1992.

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