Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-01-30
1989-07-25
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530389, 43524027, 435 7, 4351722, 424 11, 424 8591, 424 858, 935104, 935110, 436548, C07K 1500, C12N 500, G01N 5300, A61K 4300, A61K 3900
Patent
active
048515116
ABSTRACT:
Disialosyl Le.sup.a (IV.sup.3 NeuAcIII.sup.6 NeuAcIII.sup.4 FucLc.sub.4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861)secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Le.sup.a. The disialosyl Le.sup.a antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Le.sup.a antigen level, which subsequently decreased after surgical tumor removal.
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Fukushi Yasuo
Hakomori Sen-itiroh
Levery Steven B.
Nudelman Edward D.
Cheney Kay E.
Fred Hutchinson Cancer Research Center
Moskowitz Margaret
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