Monoclonal antibody that recognizes a structure common to human

Details Monoclonal antibody that recognizes a structure common to human Monoclonal antibody that recognizes a structure common to human

1984-08-15

1988-06-14

Tarcza, John E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435948, 935104, 935110, 436548, 530351, C12N 500, C12R 191, C07K 1504, A61K 39395

Patent

active

047511834

ABSTRACT:
Monoclonal antibodies that recognize a structure common to human interleukin-2 and to the light .lambda. chain of human immunoglobulin and lines of hybridoma cells that produce these monoclonal antibodies can be prepared by immunizing animals, especially mice, with human interleukin-2 (TCGF) and fusing the splenocytes obtained from the animals with animal, expecially mouse, myeloma cells to create a hybridoma. The hybridomas are raised as clones and the antibodies obtained from the individual clones tested for their specificity to human interleukin-2 (TCGF). Clones that produce antibodies with a specificity to human interleukin-2 (TCGF) are selected for further raising to prepare the antibody. The antibody is harvested from the culture medium or from the ascitic fluids of the animal, especially the mouse, with the hybridoma.

REFERENCES:
patent: 4473493 (1984-09-01), Gillis et al.
Stadler et al, "Monoclonal Antibody Against Human Interleukin 2 (IL-2) Journal of Immunology 128(4) pp. 1620-1624 (1982).
Stadler et al, "Human Interleukin-2: Biological Studies Using Purified IL-2 and Monoclonal Antibodies", Lymphokines vol. 6 pp. 117-135 (1982).
Smith et al, "Production and Characterization of Monoclonal Antibodies to Human Interleukin 2" Journal of Immunology 131(4) pp. 1808-1815 (1983).
Gillis et al, "The Biochemical and Biological Characterization of Lymphocyte Regulatory Molecules", Journal of Immunology 126(5) pp. 1978-1984 (1981).
Francis W. Ruscetti, James W. Mier, and Robert C. Gallo-Human T-Cell Growth Factor: Parameters for Production-Journal of Supramolecular Structure 13:229-241 (1980).
G. Kohler et al, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity"; Nature vol. 256, (1975) pp. 495-497.
Kearney et al, "A New Mouse Myeloma Cell Line that has Lost Immunoglobulin Expression . . . ", J. of Immun., vol. 23, No. 4, Oct. 19.
P. Lindsay et al, "The Species Specificity of Human Interleukin 2", Human Lymphokines, Academic Press (1982); pp. 479-485.
Sonneborn and Schwulera, "Production, Purification & Properties of Human Interleukin-2 (IL-2)", Technical Reports, Biotest Bulletin 3: (1982), pp. 222-227.
Kohler & Milstein, "Derivation of Specified Antibody-Producing Tissue Culture . . . ", Eur. J. Immunol. (1976) 6:511-519.
Cotton et al, "Somatic mutation and the origin of antibody diversity . . . Eur. J. Immunol. (1973), 3:135-140.
Morgan et al, "Selective In Vitro Growth of T-Lymphocytes from Normal Human Bone Marrows", Science vol. 193. (1976), 3:1007-1008.

Affiliated with

Also associated with

Rating

Monoclonal antibody that recognizes a structure common to human does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibody that recognizes a structure common to human , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody that recognizes a structure common to human will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-504872