Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-02-01
1998-09-15
Feisee, Lila
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, 5303882, 5303913, 435 71, 435326, C07K 1600, G01N 3353
Patent
active
058079998
ABSTRACT:
The present invention relates to: 1) A monoclonal antibody (mAb) that binds selectively to phosphorylated histone H1 and not to nonphosphorylated histone H1 and its use. In one embodiment, the mAb of the present invention binds selectively to histone H1 phosphorylated at the 12D11 epitope as defined herein, and 2) A cell producing a monoclonal antibody which binds selectively to phosphorylated histone H1 and has been shown to distinguish between histone H1 phosphorylated at the 12D11 epitope and histone H1 nonphosphorylated at this epitope.
REFERENCES:
patent: 5225325 (1993-07-01), Miller et al.
Bers et al., Bigkhimiia 44:993-1001, 1979.
Sevier et al., Clin Chem, 27:1797-1806, 1981.
Morrison, Science 229:1202-1207, 1985.
Sternberger et al., "Aberrant neurofilament phosphorylation in Alzheimer ease," Proc. Natl. Acad. Sci. USA, 82:4274-4276, (1985).
Cole et al., "Growth Factors That Repress Myoblast Differentiation Sustain Phosphorylation of a Specific Site on Histone H1," J. of Biol. Chem., 268(3) : 1580-1585, (Jan. 25, 1993).
Fasy et al., "Phosphorylation of H1 and H5 Histones by Cyclic AMP-Dependent Protein Kinase Reduces DNA Binding," Biochimica et Biophysica Acta, 564:322-334, (1997).
Monestier et al., "Monoclonal Anti-Histone H1 Autoantibodies From MRL 1pr/1pr MICE," Molecular Immunology, 26(8) :749-758, (1989).
Ajairo, Kozo, et al., "Subtype-specific Cyclic AMP-dependent Histone H1 Phosphorylation at the Differentiation of Mouse Neuroblastoma Cells," J. Biological Chemistry, 265(11) :6494-6500 (1990).
Muller, S. et al., "Use if histone antibodies for studying Chromatin topography and the phosphorylation of chromatin subunits," EMBO Journal, 3(10) :2431-2436 (1984).
Davis Minh-Tam
Feisee Lila
Mt. Sinai School of Medicine of the City University of New York
LandOfFree
Monoclonal antibody that distinguishes between phosphorylated an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody that distinguishes between phosphorylated an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody that distinguishes between phosphorylated an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-88782