Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-03-29
1999-08-10
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 29, 435332, 435336, 435346, 5303882, 5303887, 436538, G01N 3353
Patent
active
059358017
ABSTRACT:
A monoclonal antibody which specifically binds to an antigen on the membrane of mitochondria in apoptotic cells. The antigen is a 38 kD protein that is detectable in cells undergoing apoptosis and undetectable in normal cells. This selectivity of the monoclonal antibody provides a method of distinguishing between normal and apoptotic cells in a sample of human hemopoietic cell populations. A method for detecting and measuring cells undergoing apoptosis is also provided.
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Schlossman Stuart Franklin
Zhang Chonghui
Alter Mitchell E.
Chan Christina Y.
Dana-Farber Cancer Institute
Nolan Patrick J.
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