Monoclonal antibody subsetting human helper and killer T-cells a

Details Monoclonal antibody subsetting human helper and killer T-cells a Monoclonal antibody subsetting human helper and killer T-cells a

1983-08-18

1987-06-30

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 29, 435 68, 4351722, 435240, 435948, 530387, 935101, 935110, G01N 3350, C07K 1506, C12P 2100, C12N 500

Patent

active

046770569

ABSTRACT:
A monoclonal antibody 4A produced by a human-mouse hybridoma cell line is described. In the presence of complement, 4A subsets both cytotoxic and helper T cells creating a diagnostic tool in blood biochemistry.

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patent: 4381292 (1983-04-01), Bieber et al.
patent: 4381295 (1983-04-01), Kung et al.
patent: 4443427 (1984-04-01), Reinherz et al.
Haynes et al., 1979, "Human Lymphocyte Antigens: Production of a Monoclonal Antibody that Defines Functional T-Denied Lymphocyte Subsets", PNAS, v76, pp. 5829-5833.
Haynes et al., 1980, "Characterization of a Monoclonal Antibody that Defines an Immunoregulatory T Cell Subset . . . " PNAS, v77(5) 2914-18.
Haynes et al., 1981, "Phenotypic Characterization of Cutaneous T-Cell Lymphoma", N.E.J. Med., v304(22), pp. 1319-1323.
Reinherz et al., 1979, "Separation of Functional Human T-Cells by a Monoclonal Antibody", PNAS, v76(8), 4061-65.
Evans et al., 1977, "Detection, Isolation, and Functional Characterization of Two Human T-Cell Subclasses . . . , J. Exp. Med., v145, pp. 221-223.
Evans et al., 1978, "Two Functionally Distinct Subpopulations of Human T-Cells that Collaborate in the Generation of Cytotoxic Cells . . . " J. Imm., v120(4), 1423-1428.
Morishima et al., 1982, "Functionally Different T-Lymphocyte Subpopulations Determined by Sensitivity . . . " J. Imm., v129(3) 1091-1098.

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