Monoclonal antibody specifically recognizing N-terminal portion

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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435 7021, 53038824, C07K 1528, C12N 520, C12P 2108

Patent

active

053309090

ABSTRACT:
A monoclonal antibody specifically recognizing N-terminal portion of human calcitonin (hCT), a hybridoma producing said monoclonal antibody, a process for preparing said monoclonal antibody, and a method for detecting hCT which comprises the use of said monoclonal antibody are provided.
The above monoclonal antibody permits detection of hCT with high sensitivity.

REFERENCES:
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Seth et al., 1988, A sensitive and specific two-site enzyme-immunoassay for human calcitonin using monoclonal antibodies J. Endocrinol 119:351-357.
Hellstrom et al., 1985, In Monoclonal Antibodies for Cancer Detection and Therapy (Baldwin et al., eds), p. 20 Academic Press, London.
Motte, P., et al., The Journal of Immunology, vol. 138, 3332-3338, No. 10, May 15, 1987.
Motte, P., et al., Henry Ford Hosp. Med. J., vol. 35, Nos. 2 & 3, 129-132 (1987).
Racchetti, G., et al., Molecular Immunology, vol. 24, No. 11, pp. 1169-1176, 1987.
Scopsi, L., et al., Histochemistry 88:113-125 (1988).

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