Monoclonal antibody specifically reactive to surface of human pr

Details Monoclonal antibody specifically reactive to surface of human pr Monoclonal antibody specifically reactive to surface of human pr

1989-08-07

1991-10-08

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 435 7021, 4351722, C12N 520, C12N 1502, C07K 1528, C12P 2108

Patent

active

050554042

ABSTRACT:
Monoclonal antibodies Pes-1, Pes-2, Pes-3 and Pes-4 which are respectively produced by hybridomas hPro-1.10G (FERM BP-1986), hPro-4.10H (FERM BP-2634), hPro-5.10F and hPro-1.5F specifically bind to the surface of human prostatic epithelial cells. They do not bind to any of many other normal or tumor tissues. The monoclonal antibodies are prepared by immunizing an animal with pieces of epithelial tissue from human prostate as an antigen, fusing antibody-producing cells of the animal with myeloma cells, selecting a hybridoma which produces the antibody, cultivating the hybridoma and recovering the antibody. The monoclonal antibodies have utility for histological examination for metastatic nests in prostatic cancer, preoperative examination in prostatic cancer, diagnosis of prostatic cancer.

REFERENCES:
patent: 4446122 (1985-05-01), Chu et al.
Wright et al., Cancer Res., 43:5509-16, 1983.
Ware et al., Cancer Res. 42: 1215-22, 1982.
Campbell, "Monoclonal Antibody Technology" Elsevier, 1984, 265 p.
Frankel; PNAS 79: 903-907, 1982.
Webb; Cancer Immunol. Immunother 17: 17--17, 1984.
Finstad; PNAS 82: 2955-59, 1985.
Brawer; Cancer Res. 45: 3663-67, 1985.

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