Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-07-11
2006-07-11
Le, Long V. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S391100, C435S007400, C435S007920, C435S007940, C435S007950, C435S021000, C435S070210, C435S040520, C435S174000, C435S177000, C435S452000, C435S338000, C435S960000, C435S975000, C436S518000, C436S528000, C436S548000
Reexamination Certificate
active
07074903
ABSTRACT:
Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to TRACP 5b can be obtained by cell fusion using as antigens TRACP 5b purified from human osteoclasts. By using the monoclonal antibody, TRACP 5b in a sample can be detected specifically with a high sensitivity.
REFERENCES:
patent: 6248544 (2001-06-01), Halleen et al.
patent: WO 99/50662 (1999-10-01), None
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Copy of Communication and European Search Report dated Dec. 4, 2003.
J. Hallen et al., Journal of Bone and Mineral Research, “Tartrate-Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption”, vol. 15, No. 7, Jul. 2000, pp. 1337-1345.
Igarashi Yoshihiko
Katayama Katsuhiro
Miura Toshihide
Ohashi Tatsuya
Sasagawa Kumiko
Grun James L.
Le Long V.
Nitto Boseki Co. Ltd.
Westerman Hattori Daniels & Adrian LLP
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