Monoclonal antibody specific to human .alpha..sub.2 -plasmin inh

Details Monoclonal antibody specific to human .alpha..sub.2 -plasmin inh Monoclonal antibody specific to human .alpha..sub.2 -plasmin inh

1991-06-17

1996-07-09

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241521, 43524027, 4351722, 435 7021, 5303881, 53038822, 53038825, 530864, 530866, A61K 3900, C07K 1528

Patent

active

055342558

ABSTRACT:
This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.

REFERENCES:
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patent: 4514505 (1985-04-01), Canfield et al.
Chemical Abstracts, vol. 100, No. 1, Jan. 2, 1984 p. 241, ref. No. 2752d.
Chemical Abstracts, vol. 88, No. 21, May 22, 1978 p. 400, ref. No. 150074h.
Moroi et al, The Journal of Biological Chemistry, vol. 251, No. 19, 1976, pp. 5956-5965.
Kohler et al, Nature vol. 256, Aug. 7, 1975, pp. 495-497.
Sevier et al, Clinical Chemistry, vol. 27. No. 11, 1981, pp. 1797-1806.

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