Monoclonal antibody specific to a novel glycoprotein antigen on

Details Monoclonal antibody specific to a novel glycoprotein antigen on Monoclonal antibody specific to a novel glycoprotein antigen on

1988-08-26

1991-12-31

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4351722, 43524027, 436548, 530387, 935104, C12Q 100, G01N 3353, C12N 1500, C12N 500

Patent

active

050772201

ABSTRACT:
A hybridoma cell line is provided which is capable of producing monoclonal antibodies which bind to a unique determinant site on the surface and/or in the cytoplasm of human breast carcinoma cells and carcinoma cells of other adenocarcinomas and on the surface of normal human breast epithelial cells. The cell line of the invention was developed by immunizing mice with a select group of immunogens and a conventional myeloma cell line for fusion with the murine splenocytes harvested.
The monoclonal antibody is identified as the BrE2 monoclonal antibody. The antigen is characterized as a high molecular weight glycoprotein complex having a molecular exceeding 400,000 daltons. This monoclonal antibody is especially useful for diagnostic, prognostic and therapeutic applications in human breast cell carcinoma.

REFERENCES:
H. M. Geysen et al., Proc. Natl. Acad. Sci., 81: 3998-4002 (1984).
Griffiths, A. et al., Int Jour Cancer 40:319-327 (1987).
Burchell, J. et al., Jour Immunol. 131(1):508-513 (1983).
Gendler, S. et al., PNAS 84:6060-6064 (1987).
Arklie, J. et al., Biol Abstr. 73 (1982) #26174.
van Hell, H. et al., in "Alternative Immunoassays", (Collins, ed), Wiley & Sons, publ. 1985, pp. 39-58.

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