Monoclonal antibody specific to a novel epitope of the LFA-1 ant

Details Monoclonal antibody specific to a novel epitope of the LFA-1 ant Monoclonal antibody specific to a novel epitope of the LFA-1 ant

1987-11-02

1991-03-26

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 11, 424 8591, 424 34, 4241722, 42424027, 424948, 436503, 436548, 530387, 530391, 530809, 935104, 935110, A61K 39395, G01N 33567, G01N 33577, C12N 1500

Patent

active

050028693

ABSTRACT:
A monoclonal antibody which binds preferentially to a subset of the human CD8 lymphocyte population whereby to positively and precisely distinguish between cytotoxic effector and supressor effector cells in the CD8 cell population. The monoclonal antibody recognizes a novel epitope of LFA-1 antigen by means of which it can bind CD8 cells which express the eptope on a surface antigen thereof. The CD8 subset cell population to which this anitbody binds preferentially is the CD8 cytotoxic effector population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and positive therapeutic applications thereof to be utilized.

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