Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-01-12
1989-09-12
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 68, 4351722, 43524027, 435948, 530387, 530809, 935104, C07K 1514
Patent
active
048659711
ABSTRACT:
A hybrid cell line capable of producing monoclonal antibodies uniquely specific to human neutrophils and eosinophils and exhibiting no specificity for lymphocytes, basophils and monocytes. Further there is noreactivity with acute leukemia cells. One of the partners in the hybridoma fusion of a mouse spleen cell developed from using human granulocytes as the immunization agent. The monoclonal antibody further is capable of being used to enumerate and isolate neutrophils in normal peripheral blood and possibly in blood of patients with acute leukemia.
REFERENCES:
Lopez et al., British Journal of Hematology, 57, 489-494, 1984.
Lopez et al., Journ. Immunol., 134, 3969-3977, 1985.
Hofheinz David E.
Kortright Kenneth H.
Toedter Gary P.
Cass Myron C.
Coulter Corporation
Saunders David A.
Warden Robert J.
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