Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-05-17
1996-07-16
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
43524027, 435 7021, 4351722, 435723, 435261, 5303882, 53038822, G01N 3353, C12N 520, C07K 1628
Patent
active
055366414
ABSTRACT:
An antigen which is specific to vascular endothelium is described. Described is a cell surface antigen which consists of four subunits, of 190, 145, 125 and 110 kd as determined by SDS-PAGE under reducing conditions as is a monoclonal antibody specific to this antigen. Uses, both diagnostic and therapeutic, are also described.
REFERENCES:
Rettig et al., "Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer", Proc. Natl. Acad. Sci. USA 89: 10832-10836 (11-92).
Schlingemann et al., "Differential Expression of Markers for Endothelial Cells, Pericytes and Basal Lamina in the Microvasculature of Tumors and Granulation Tissue", Amer. J. Path. 138(6): 1335-1347 (1991).
Garin-Chesa et al., "Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers", Proc. Natl. Acad. Sci. USA 87: 7235-7239 (Sep. 1990).
Ruiter et al., "Monoclonal Antibody-Defined Human Endothelial Antigens as Vascular Markers", J. Invest. Derm. 93(2) (supp): 255-32S (Aug. 1989).
Goerdt et al., Exp. Cell Biol., 57:185-192, 1989.
Garin-Chesa Pilar
Old Lloyd J.
Rettig Wolfgang J.
Sanz-Moncasi Maria P.
Stockert Elisabeth
Hutzell Paula K.
Memorial Sloane Kittering Cancer Center
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