Monoclonal antibody specific for the adhesion function domain of

Details Monoclonal antibody specific for the adhesion function domain of Monoclonal antibody specific for the adhesion function domain of

1988-03-07

1991-05-28

Kepplinger, Esther L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530388, 530380, 530828, 43524027, 435 691, 435 7021, 4351722, 424 858, A01K 39395

Patent

active

050196480

ABSTRACT:
A hybrid cell line is developed which produces a monoclonal antibody which binds to a unique antigenic site expressed on the surface of phagocytic cells. The monoclonal antibody binds to and activates a specific domain of the CD11b glycoprotein so as to inhibit adhesion dependent functions of the phagocytic cell, but it does not affect other phagocytic functions. This monoclonal antibody can be used as a reactant in an in vitro diagnostic immunoassay for detecting the unique antigenic site on the surface of normal human neutrophils.

REFERENCES:
patent: 4840793 (1989-06-01), Todd, III et al.
Dana, N. et al., (I), "Two Functional Domains in the Phagocyte Membrane Glycoprotein Mo1 Identified with Monoclonal Antibodies", J. Immunol. 137:3259-3263, Nov. 15, 1986.
Dana, N. et al., (II) "Dysfunctional Mo1 Glycoprotein is Present on a Subline of the KG1 Myelogenous Leukemia Cell Line", J. Immunol. 138(10):3549-3554, May 10, 1987.
Letvin, N. L. "Conservation of Myeloid Surface Antigens on Primate Granulocytes," Blood 61(2):408-410, 1983.
M. A. Arnaout et al., Deficiency of Two Human Leukocyte Surface Membrane Glycoproteins Mo1 and LFA-2, Fed. Proc 44(10): 2664-2670 (Jul., 1985).
R. F. Todd III et al., Subcellular Localization of the Large Subunit of Mo1 (Mo1.alpha., A Surface Glycoprotein Associated with Neutrophil Adhesion, J. Clin. Invest. 74:1280-1290 (1984).
A. A. TeVelde et al., Antibodies to LFA-1 and Related Molecules Inhibit Conjugate Formation Between Human Peripheral Blood Monocytes and Melanoma Cells, Chem Abstracts 104:500 (No. 184712d) (1986).

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