Monoclonal antibody specific for novel PKA binding proteins

Details Monoclonal antibody specific for novel PKA binding proteins Monoclonal antibody specific for novel PKA binding proteins

1997-05-29

1998-10-13

Cunningham, Thomas M.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Fused or hybrid cell, per se

435326, 435334, 5303581, 53038822, 5303872, C12N 512, C07K 1628, C12P 2108

Patent

active

058211250

ABSTRACT:
The present invention provides novel PKA-binding polypeptides, nucleic acids that encode the polypeptides and antibodies specifically immunoreactive with the polypeptides.

REFERENCES:
Coghlan et al 1995 Science 267:108.
Klauck et al 1996 Science 271:1589.
Allen et al., "Cyclosporin: A Therapy for Wegener's Granulomatosis" in ANCA-Associated Vasculitides: Immunological and Clinical Aspects, Gross (ed.) New York: Plenum Press (1993), pp. 473-476.
Belldegrun et al., "Interferon-.alpha. Primed Tumor-Infiltrating Lymphocytes Combined with Interleukin-2 and Interferon-.alpha. as Therapy for Metastatic Renal Cell Carcinoma", J. Urol. 150:1384-1390 (1993).
Bougneres et al., "Limited Duration of Remission of Insulin Dependency in Children with Recent Overt Type I Diabetes Treated with Low-Dose Cyclosporin", Diabetes 39:1264-1272 (1990).
Bregman et al., "Molecular Characterization of Bovine Brain P75, a High Affinity Binding Protein for the Regulatory Subunit of cAMP-dependent Protein Kinase II.beta.*", J.Biol.Chem. 266:7207-7213 (1991).
Bruton and Koeller, "Recombinant Interleukin-2", Pharmacotherapy 14:635-656 (1994).
Brynskov, "Cyclosporin in Crohn's disease", Dan.Med.Bull. 41:332-344 (1994).
Carr et al., "Association of the type II cAMP-dependent Protein Kinase with a Human Thyroid RII-anchoring Protein", J.Biol.Chem. 267:13376-13382 (1992).
Carr et al., "Interaction of the Regulatory Subunit (RII) of cAMP-dependent Protein Kinase with RII-anchoring Proteins Occurs through an Amphipathic Helix Binding Motif*", J.Biol.Chem. 266:14188-14192 (1991).
Carr et al., "Localization of the cAMP-dependent Protein Kinase to the Postsynaptic Densities by A-Kinase Anchoring Proteins", J.Biol.Chem. 267:16816-16823 (1992).
Choi and Targan, "Immunomodulator Therapy in Inflammatory Bowel Disease", Dig.Dis and Sci. 39:1885-1892 (1994).
Coghlan et al., "Cloning and Characterization of AKAP 95, a Nuclear Protein That Associates with the Regulatory Subunit of Type II cAMP-dependent Protein Kinase*", J.Biol.Chem. 269:7658-7665 (1994).
Cooper et al., "Atopic Dermatitis: Recent Trends in Pathogenesis and Therapy", J.Invest.Derm 102:128-137 (1994).
Cuellar et al., "Treatment of psoriatic arthritis", Balliere's Clin.Rheum. 8:483-498 (1994).
DeCamilli et al., "Heterogeneous Distribution of the cAMP Receptor Protein RII in the Nervous System: Evidence for Its Intracellular Accumulation of Microtubules, Microtubule-organizing Centers, and in the Area of the Golgi Complex", J.Cell.Biol. 103:189-203 (1986).
de Groen et al., "Central Nervous System Toxicity After Liver Transplantation", N.Eng.J.Med. 317:861-866 (1987).
Dillman, "The Clinical Experience with Interleukin-2 in Cancer Therapy", Cancer Biotherapy 9:183-209 (1994).
Dougados and Torley, "Efficacy of Cyclosporin A in Rheumatoid Arthritis: Worldwide Experience", Br.J.Rheum 32(suppl 1):57-59 (1993).
Eidelman et al., "Neurologic Complications of FK 506", Transplnt.Proc. 23:3175-3178 (1991).
Elliot and Chase, "Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide", Diabetologia 34:362-365 (1991).
Ellis et al., "Cyclosporine Improves Psoriasis in a Double-blind Study", JAMA 256:3110-3116 (1986).
Feldt-Rasmussen et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", Diabetes Medicine 7:429-433 (1990).
Feutren, "Renal Morphology After Cyclosporin A Therapy in Rheumatoid Arthritis Patients", International Kidney Biopsy Registry of Cyclosporin (Sandimmum) in Autoimmune Diseases Brit.J.Rheum. 32(suppl 1):65-71 (1993).
Forre et al., "An Open, Controlled, Randomized Comparison Of Cyclosporine And Azathioprine In The Treatment Of Rheumatoid Arthritis: A Preliminary Report", Arthritis Reheum. 30:88-92 (1987).
Fradin et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", J.Am.Acad.Derm. 25:1065-1067 (1991).
Fung et al., "Adverse Effects Associated With the Use of FK 506", Transplant.Proc. 23:3105-3108 (1991).
Glantz et al., "cAMP Signaling in Neurons: Patterns of Neuronal Expression and Intracellular Localization for a Novel Protein, AKAP 150, that Anchors the Regulatory Subunit of cAMP-Dependent Protein Kinase II.beta.", Mol.Cell.Biol. 3:1215-1288 (1992).
Glantz et al., "Characterization of Distinct Tethering and Intracellular Targeting Domain in AKAP75 a Protein That Links cAMP-dependent Protein Kinase II.beta. to the Cytoskeleton*", J.Biol.Chem. 268:12796-12804 (1993).
Hafner et al., "Machanism of Inhibition of Raf-1 by Protein Kinase A," Mol.Cell.Biol. 14:6696-6703 (1994).
Haydon, et al., "New immunosuppressive treatment in transplantation medicine," Bailliere's Clinical Gastroenterology, vol. 8, pp. 445-464, (1994).
Hirsch et al., "Cloning and Expression of an Intron-less Gene for AKAP 75, an Anchor Protein for the Regulatory Subunit of cAMP-dependent Protein Kinase II.beta.*", J.Biol.Chem. 267:2131-2134 (1992).
Hulton et al., "Long-term cyclosporin A treatment of minimal-change nephrotic syndrome of childhood", Pediatr.Nephrol. 8:401-403 (1994).
Jenner et al., "Cyclosporin A treatment of young children with newly-diagnosed Type 1 (insulin-dependent) diabetic mellitus", Diabetiologia35:884-888 (1992).
Kahan, "Cyclosporine", N.Eng.J.Med. 321:1725-1738 (1989).
Kaplan, "Recent Advances in Cytokine Therapy in Leprosy", J.Infect.Dis. 167(suppl 1):s18-22 (1993).
Keryer et al., "A High-Affinity Binding Protein for the Regulatory Subunit of cAMP-Dependent Protein Kinase II in the Centrosome of Human Cells", Exp.Cell Res. 204:230-240 (1993).
Lange and Reiderer, "Glutamatergic Drugs in Parkinson's Disease", Life Sciences 55:2067-2075 (1994).
Leaker and Cairns, "Clinical aspects of cyclosporin nephrotoxicity", Br.J.Hosp.Med. 52:520-524 (1994).
Lockerbie et al., "Anchoring of protein kinase A is required for mediating the inhibitory effects of 3', 5'-cyclic adenosine monophosphate on IL-2 transcription in human T cells" J.Cell Biochem. Suppl.21A:76 Abstract D2155 (1995).
Ludwin and Alexopolulou, "Cyclosporin A Nephropathy in Patients with Rheumatoid Arthritis", Br. J.Rheum. 32(suppl 1):60-64 (1993).
MacFarlane et al., "The Hematologic Toxicity of Interleukin-2 in Patients with Metastatic Melanoma and Renal Cell Carcinoma", Cancer 75:1030-1037 (1995).
Manev et al., "Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate", Brain Res. 624:331-335 (1993).
Martin et al., "Follow-up of cyclosporin A treatment in Type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects", Dibetologia 34:429-434 (1991).
Mason, "Pharmacology of Cyclosporine (Sandimmune) VII. Pathophysiology and Toxicology of Cyclosporine in Humans and Animals", Pharmacol.Rev. 42:423-434 (1989).
McCartney et al., "Cloning and Characterization of A-kinase Anchor Protein 100(AKAP100)", J.Biol. Chem. 270:9327-9333 (1995).
Meldrum, "The role of glutamate in epilepsy and other CNS disorders", Neurology 44(suppl 8):S14-S23 (1994).
Merchant et al., "Immunotherapy for malignant glioma using human recombinant Interleukin-2 and activated autologous lymphocytes", J.Neuro. 8:173-188 (1990).
Meyrier, "Treatment of nephrotic syndrome with cyclosporin A. What remains in 1994?", Nephrol.Dial.Transplant 9:596-598 (1994).
Morris, "New Small Molecule Immunosuppressants for Transplantation: Review of Essential Concepts", J.Heart and Lung Transplant. (Nov./Dec) pp. S275-S285 (1993).
Olney, "Excitatory Transmitter Neurotoxicity", Neurobiology of Aging 15:259-260 (1994).
Pacor et al., "Cyclosporin in Behcet's Disease: Results in 16 Patients after 24 Months of Therapy", Clin Rheum. 13:224-227 (1994).
Pierce et al., "Cellular Therapy: Scientific Rationale and Clinical Results in the Treatment of Metastatic Renal-Cell Carcinoma", Sem. Oncol. 22:74-80 (1995).
Platz et al., "Nephrotoxicity Following Orthotopic Liver Transplantation", Transplantation 58:170-178 (1994).
Reece et al., "Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin", Bone Marrow Transplant. 8:393-401 (1991).
Reitamo and Granlund, "Cyclosporin A in the

Affiliated with

Also associated with

Rating

Monoclonal antibody specific for novel PKA binding proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibody specific for novel PKA binding proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody specific for novel PKA binding proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-312715