Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-03-30
1989-12-12
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 3, 424 71, 435 7021, 4351722, 43524027, 435948, 436548, 436800, 436808, 436813, 128630, 128751, 530387, 530388, 530808, 530809, G01N 33577
Patent
active
048867454
ABSTRACT:
The present invention is concerned with novel monoclonal antibodies specific for an antigenic site on a protein characteristic of a human basal cell and a malignant squamous cell. The antibodies do not bind to mesenchymal cells such as fibroblasts and endothelial cells. The protein on the cell surface which binds to one of the antibodies has a molecular weight of about 120,000 as determined by one dimensional gel electrophoresis. The antibodies find use in diagnostic methods such as the detection of malignant cells, e.g., the detection of residual tumor cells in skin subjected to microscopically-controlled surgery.
REFERENCES:
patent: 4361544 (1982-11-01), Goldenberg
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4448890 (1984-05-01), Smetana et al.
Oseroff et al., Journal of Investigative Dermatology, vol. 84:257-261, 1985.
Oseroff et al., Clinical Research, vol. 30, No. 2:1982.
Morhenn et al., Journal of Investigative Dermatology, vol. 81:1275-/3/5, 1983.
Suter et al., Journal Immunologica Methods, vol. 39, 407-411, 1980.
Tromovich et al., Arch Dermatol, vol. 110: 231-232, Aug. 1974.
Frederic E. Mohs, Archives of Surgery, vol. 42:379-295, 1974.
Leitereg Theodore J.
Nucker Christine M.
Syntex Inc.
LandOfFree
Monoclonal antibody specific for human basal cell surface antige does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody specific for human basal cell surface antige, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody specific for human basal cell surface antige will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2121432