Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-01-03
1989-05-16
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
43524027, 435 68, 4351722, 935104, 424 858, 424 8591, 530808, C12N 500, A61K 39395
Patent
active
048311170
ABSTRACT:
A hybrid cell line yields a monoclonal antibody which is highly restricted to B-lineage lymphoblastic leukemia cells and their progenitors.
REFERENCES:
Uckum, F. M. et al. (II) "Increased Efficiency in Selective Elimination of Leukemia Cells by a Combination of a Stable Derivative of Cyclophosphamide and a Human B-Cell-Specific Immunofoxin Containing Pokeweed Antiviral Protein", Cancer Research 45:69-75, Jan. 1985.
Uckun, F. M. et al. (III) "Heterogeneity in Leukemia Cell Populations: A Clear Rationale for Use of Combination Protocols for Ex Vivo Marrow Purging," Transplantation Proceedings, vol. XVII, No. 1, Feb. 1985, pp. 462-464.
Uckun, F. M. et al. (IV) "Immunotoxin-Mediated Elimination of Clonogenic Tumor Cells in the Presence of Human Bone Marrow," J. Immunology, vol. 134, No. 3, Mar. 1985, pp. 2010-2016.
Nadler, L. M. et al. "A Unique Cell Surface Antigen Identifying Lymphoid Malignancies of B Cell Origin," J. Clin. Invest., vol. 67, Jan. 1981, pp. 134-140.
Stashenko, P. et al. "Characterization of a Human B Lymphocyte-Specific Antigen," J. Immunology, vol. 125, No. 4, Oct. 1980, pp. 1678-1685.
Uckun, F. et al. (I) "Selective Elimination of Clonogenic Tumor Cells from Human Bone Marrow by Immunotoxins," Abstract, 1984.
C. S. Abramson et al., J. Immunology, 126, 83 (1981).
L. M. Nadler et al., J. Immunology, 131, 244 (1983).
F. M. Uckun et al., J. Immunology, 134, 2010 (1985).
Copy of ATCC Deposit Contract with respect to hybridoma IST 1586 (ATCC HB 8903), dated Sep. 16, 1985.
Cheney Kay E.
Moskowitz Margaret
LandOfFree
Monoclonal antibody specific for human B-cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody specific for human B-cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody specific for human B-cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2323553