Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
1997-12-16
Chan, Christina
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241371, 4241411, 4241781, 5303873, 5303875, 53038825, 5303911, 5303913, A61K 39395, C07K 1618
Patent
active
056981970
ABSTRACT:
The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularly, the invention is directed to a monoclonal antibody, or an antigen-binding fragment thereof, reactive with in vivo produced advanced glycosylation endproducts (AGEs), which monoclonal antibody or antigen binding fragment thereof demonstrates an immunological binding characteristic of monoclonal antibody 4G9 as produced by hybridoma 4G9, deposited with the American Type Culture Collection (ATCC) and assigned Accession Number CRL 11626, on Apr. 27, 1994. In a specific embodiment, the 4G9 antibody is used in a sandwich ELISA to detect ApoB-AGE, IgG-AGE, collagen-AGE, serum-AGE peptides and proteins and urinary-AGE peptides and proteins.
REFERENCES:
Harlow et al. (1988) Antibodies A laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 141,148,238,321,626,287.
Queen et al. (1989) Proc. Natl. Acad. Science. USA. vol. 86:10029-10033.
Araki et al., 1992, J. Biol. Chem. 267:10211-14.
Brownlee et al., 1983, J. Exp. Med. 158:1739-1744.
Bucala et al., 1993, Proc. Natl. Acad. Sci. USA 90:6434-38.
Horiuchi et al., 1991, J. Biol. Chem. 266:7329-32.
Kohn et al., 1984, Diabetes 33:57-59.
Makita et al., 1992, J. Biol. Chem. 267:5133-38.
Makita et al., 1992, Science 258:651-653.
Nakayama et al.,1989, Biochem. Biophys. Res. Commun. 162:740-745.
Founds Henry W.
Sadeghi Homayoun
Alteon Inc.
Cech Emma
Chan Christina
LandOfFree
Monoclonal antibody specific for advanced glycosylation endprodu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody specific for advanced glycosylation endprodu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody specific for advanced glycosylation endprodu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-202971